Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant

Oncoletter provides you with quotes from the abstract's conclusions. To see more, go the ASCO Meeting Library while clicking on the link of the study-titles (to see videos and slides needs a payable registration)
 
 
Curtis Andrew Lachowiez, Gautam Borthakur, Sanam Loghavi, et al.
 
The abstract concludes: 
IVO+VEN +AZA therapy is well tolerated and highly effective for patients with IDH1 mutated AML. Follow up and accrual is ongoing to better define duration and biomarkers of response. Clinical trial information: NCT03471260
 
CCO Independent Conference Coverage of the 2020 ASCO Virtual Scientific Meeting:
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Courtney Denton Dinardo, Andre C. Schuh, Eytan M. Stein, et al.
 
The abstract concludes: 
Combining ENA + AZA resulted in significantly improved response rates and durations, and was generally well-tolerated in older patients with mIDH2 ND-AML. The impact of subsequent Tx on OS/EFS and new translational data will be presented at the meeting. Clinical trial information: NCT02677922.
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Jorge E. Cortes, Elza Lomaia, Anna Turkina, et al.
 
The abstract concludes: 
OPTIC IA shows a trend toward dose-dependent efficacy and safety and may provide a refined understanding of the PON benefit:risk profile and its relation to dose. Data from longer follow-up may support an alternate dosing regimen for pts with CP-CML.
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Muna Qayed, Carrie L Kitko, Kwang Woo Ahn, et al.
 
The abstract concludes: 
This validated p-DRI successfully stratified children with AML and ALL for prognostication undergoing allogeneic transplantation.
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Sarah Griffith, Alyssa L. Fenech, Ashley Nelson, et al.
 
The abstract concludes: 
Approximately one fifth of patients undergoing HCT experienced clinically significant PTSD symptoms at six months post-transplant. Patients’ baseline QOL and psychological symptoms emerged as important predictors of their risk for PTSD at six months post-HCT. Thus, interventions to prevent and treat PTSD symptoms in HCT recipients are clearly warranted.
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The abstract concludes: 
P+A had a comparable safety profile to A alone, did not increase myelosuppression, and maintained A dose intensity. Although not statistically significant, P+A increased OS, EFS, and response rates vs A, particularly in pts with higher-risk MDS. Further evaluation of P+A vs A is ongoing in a randomized phase. Clinical trial information: NCT02610777.
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David Andrew Sallman, Monzr Al Malki, Adam Steven Asch, et al.
 
The abstract concludes: 
Magrolimab is a macrophage targeting immunotherapy that with AZA is well tolerated with durable efficacy in MDS, AML, particularly TP53 mutant, a poor prognostic group. A potential registration single arm MDS cohort is ongoing (NCT03248479). ENHANCE, a randomized Ph3 MDS trial is planned. Additional patients/analyses will be reported. Funded by Forty Seven and CIRM. Clinical trial information: NCT03248479.
 
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Farhad Ravandi, Roland B. Walter, Marion Subklewe, et al.
 
The abstract concludes: 
AMG 330 dosed up to 720 μg/day provided early evidence of acceptable safety profile, drug tolerability and anti-leukemic activity, and supports further dose escalation. Clinical trial information: NCT02520427.
 
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Hematologic Malignancies (Abstracts #7500, 7501, 7508)
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